Phenylpropanoids and polyketides
Medchemexpress LLC AKT-IN-6 | 1430056-54-4 | 99.1% | 389.43 | 1 ML
AKT-IN-6 is a potent Akt inhibitor that targets Akt1, Akt2, and Akt3 with IC50s below 500 nM. Akt is a central node in cell signaling, and its aberrant activation is linked to various complex diseases, including type-2 diabetes and cancer.
- Potent Akt inhibitor
- Targets Akt1, Akt2, and Akt3
- Suitable for research applications
Selleck Chemical LLC Chalcone
Chalcone (benzylideneacetophenone phenyl styryl ketone benzalacetophenone -phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds which are known collectively as chalcones with antibacterial antifungal antitumor and anti-inflammatory properties
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 100 G
This product, 4'-Methoxychalcone, regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
- Regulates adipocyte differentiation
- Activates PPARγ
- Modulates adipokine expression related to insulin sensitivity
- Stable under recommended storage conditions
- White to light yellow solid appearance
- High purity of 99.8%
Medchemexpress LLC 4'-Hydroxychalcone | 2657-25-2 | 1 ML
4'-Hydroxychalcone is a chalcone isolated from licorice root with hepatoprotective activity. It inhibits TNFa-induced NF-κB activation via proteasome inhibition. It also induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
- Isolated from licorice root
- Exhibits hepatoprotective activity
- Inhibits TNFa-induced NF-κB activation through proteasome inhibition
- Induces rapid potassium release from mitochondrial vesicles
- Causes deterioration of respiratory control and oxidative phosphorylation
- Affects cancer cell viability
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 | C15H12O | 25g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Apexbio Technology LLC Naringenin 480-41-1 100mg
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Medchemexpress LLC Chalcone | 94-41-7 | 100.0% | 50 MG
Chalcone is the parent α,β-unsaturated ketone scaffold used widely as a small-molecule research chemical and synthetic building block. Provided as a high-purity solid, it is used in medicinal chemistry, biochemical assays, and the synthesis of chalcone derivatives. Typical identifiers: CAS 94-41-7; formula C15H12O; molecular weight 208.25 g/mol.
- High purity suitable for research use.
- Useful building block for synthesis of bioactive derivatives.
- Compatible with DMSO; available as solution for screening.
- Supplied with certificate of analysis and safety data for quality and safety.
- Available in small-scale quantities for discovery research.
Medchemexpress LLC (±)-Naringenin | 67604-48-2 | 99.8% | 272.26 | 50 G
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. It promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells and exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research.
- Regulates acute and chronic inflammation responses
- Exhibits antioxidant effects
- Provides neuroprotective benefits
- Offers liver-protective properties
- Shows anti-cancer effects
- Promotes vasodilation in endothelial cells
- Inhibits Toll-like receptor 4/NF-κB signaling
Medchemexpress LLC Phospho-AKT Thr308 100uL | 100uL
Phospho-AKT(Thr308) Antibody (YA5837) (YA5837) is a Rabbit-derived and non-conjugated IgG monoclonal antibody targeting to Phospho-AKT(Thr308)
Medchemexpress LLC Chalcone dibromide | 611-91-6 | 95.0% | 368.06 g/mol | C15H12Br2O | 100 MG
Chalcone dibromide is a dibrominated chalcone derivative supplied as a white to off-white solid for research use. It serves as a versatile synthetic building block and bioactive compound in medicinal chemistry and organic synthesis, commonly used to prepare heterocycles and to evaluate biological activity.
- Dibrominated chalcone useful as a synthetic intermediate.
- Solid, white to off-white appearance for easy handling.
- Reported purity of 95.0% for research applications.
- Available in multiple pack formats including 100 mg and DMSO solutions.
- Structural identifiers provided (SMILES) to support characterization.
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 5 MG
AKT-IN-23 is an AKT inhibitor that can be used in cancer research. This product is designed for research use only and has not been fully validated for medical applications.
- Can be used in cancer research
- Inhibitor of AKT
Medchemexpress LLC Pinostrobin chalcone | 18956-15-5 | 99.9% | 270.28 g/mol | C16H14O4 | 10 MG
Pinostrobin chalcone is a naturally occurring chalcone derivative supplied as a high-purity research standard for in vitro biological and analytical studies. It has reported cytotoxic activity against MDA-MB-231 and HT-29 cancer cell lines (IC50 = 20.42 ± 2.23 μg/mL and 22.51 ± 0.42 μg/mL). The compound is provided as a solid and should be stored sealed at 4°C, protected from moisture and light.
- High purity (99.94%).
- Molecular weight 270.28 g/mol.
- Chemical formula C16H14O4.
- CAS number 18956-15-5.
- Suitable for in vitro cytotoxicity and analytical assays.
- Provided in a 10 MG package for laboratory use.
- Store at 4°C, sealed, away from moisture and light.